CoMFA and CoMSIA Studies on 1H-Furan-2,5-dione and 1H-Pyrrole-2,5-dione as PGE2Production Inhibitor
نویسندگان
چکیده
منابع مشابه
1-(2-Methoxyphenyl)-1H-pyrrole-2,5-dione
In the title compound, C(11)H(9)NO(3), the dihedral angle between the meth-oxy-benzene and 1H-pyrrole-2,5-dione rings is 75.60 (10)°. The C atom of the meth-oxy group is close to coplanar with its attached ring [deviation = 0.208 (2) Å]. In the crystal, weak aromatic π-π stacking [centroid-centroid separation = 3.8563 (13) Å] occurs between inversion-related pairs of benzene rings.
متن کامل3,4-Bis(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
In the title compound, C(18)H(15)NO(4), the benzene rings form quite different dihedral angles [16.07 (1) and 59.50 (1)°] with the central pyrrole ring, indicating a twisted mol-ecule. Conjugation is indicated between the five- and six-membered rings by the lengths of the C-C bonds which link them [1.462 (3) and 1.477 (3) Å]. The most prominent feature of the crystal packing is the formation of...
متن کامل3,4-Bis[1-(prop-2-ynyl)-1H-indol-3-yl]-1H-pyrrole-2,5-dione
In the title mol-ecule, C26H17N3O2, both indole ring systems are essentially planar, with maximum deviations of 0.019 (2) and 0.033 (1) Å for the N atoms, and form dihedral angles of 34.40 (9) and 45.06 (8)° with the essentially planar pyrrole ring [maximum deviation = 0.020 (2) Å]. The dihedral angle between the two indole ring systems is 58.78 (6)°. In the crystal, mol-ecules are connected by...
متن کامل1-(2-Hydroxyethyl)-3-[(2-hydroxyethyl)amino]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
There are four molecules in the asymmetric unit of the title compound, C(16)H(17)N(3)O(4), in which the dihedral angles between the indole ring system and maleimide ring are 4.5 (3), 8.3 (3), 8.4 (2) and 10.4 (2)°. In the crystal, mol-ecules are linked by numerous N-H⋯O and O-H⋯O hydrogen bonds, generating a three-dimensional network.
متن کاملQuinazoline-2,4(1H,3H)-dione
In the title compound, C(8)H(6)N(2)O(2), inter-molecular N-H⋯O hydrogen bonds involving the amine and carbonyl groups create centrosymmetric dimers between adjacent nearly coplanar mol-ecules. These dimers are further connected by weak N-H⋯O hydrogen bonds, forming a two-dimensional network. Mol-ecules are packed in the crystal structure with adjacent benzene and pyrimidine rings approximately ...
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ژورنال
عنوان ژورنال: Bulletin of the Korean Chemical Society
سال: 2012
ISSN: 0253-2964
DOI: 10.5012/bkcs.2012.33.1.305